STUDIES

Often we do not understand what it is that keeps us from falling pregnant and we do not know what exactly it is that the medications that we take do.

Hopefully we can give you some insight into what it is that the ingredients in Fertivor have shown to do for women who are trying to get pregnant.

If you are still unsure after having read this please consult your doctor as it is very important that you know what certain medication or supplements are doing to help. Often people take medication that will not work for them because of their specific condition. This can be expensive and even dangerous so here we go.

Fertivor is a natural product which contains the following ingredients:

N ACETYL L CYSTEINE (NAC)

NAC AND OVULATION

Studies have shown that NAC can drastically improve ovulation rates. One study found that those who took a NAC supplement during their cycle saw 52% improvement in ovulation. This is compared to a previous cycle when the women took clomiphene citrate, commonly referred to as Clomid, where ovulations rates improved by a mere 18%.

Source: https://www.ncbi.nlm.nih.gov/pubmed/17364286

NAC AND POLYCISTIC OVARY SYNDROME (PCOS)

What is PCOS?

Polycystic ovary syndrome (PCOS) is a condition that affects a woman’s hormone levels.

Women with PCOS produce higher-than-normal amounts of male hormones. This hormone imbalance causes them to skip menstrual periods and makes it harder for them to get pregnant.

PCOS is a ”syndrome,” or group of symptoms that affects the ovaries and ovulation. Its three main features are:

  • Cysts in the ovaries
  • High levels of male hormones
  • Irregular or skipped periods

PCOS is one of the most common causes of infertility in women. Studies have shown that up to 10% of women of a conceiving age suffer from PCOS.

The first medication option for women with PCOS is usually clomiphene citrate, commonly referred to as Clomid. However, one of the most common problems with Clomid treatment is that up to 40% of women with PCOS are resistant to Clomid.

NAC is a mucolytic drug with insulin-sensitizing properties that has been used successfully as a supporting therapy in subjects with clomiphene resistant PCOS.

Recent studies have shown that a combination of clomiphene and NAC considerably increased both ovulation and pregnancy rates in women with clomiphene resistant PCOS. NAC has multiple biological effects, two of which are potentially and directly related to pregnancy rate improvement. NAC has mucolytic action; thus, it can revoke the negative effect of clomiphene on cervical mucus. Simultaneously, it has insulin sensitizing effect that could assist in issues related to PCOS. The negative influence of clomiphene on cervical mucus can create a ”hostile” environment for conception.

In short therefore these studies have shown that NAC may:

  • Revoke the negative effect of clomiphene on cervical mucus;
  • Have an insulin sensitizing effect that could assist in issues related to PCOS.

Source: Effect of N-acetyl-cysteine after ovarian drilling in clomiphene citrate-resistant PCOS women: a pilot study.Nasr A, Reprod Biomed Online. 2010 Mar; 20(3):403-9

Youssef G, Meguid Ali A, Alaa N, Makin B, Waly M, AbouSetta A. N-acetyl-cysteine in anovulatory women: the impact of postcoital test. Middle East Fertil Soc J. 2006; 11:109-112.

NAC AND EGG QUALITY

NAC has also been shown to improve egg quality. This is particularly important if you are going through IVF treatments or are trying to get pregnant when you are older than 35. In a study of women suffering from PCOS, the group who received a NAC supplement saw a decrease in the amount of abnormal ovarian cells and the most significant increase in embryo quality when compared to other groups (2). NAC can improve the quality of your eggs and their chances of fertilization.

Source: https://www.ncbi.nlm.nih.gov/pubmed/25482371

NAC AND PREMATURE BIRTH / RECURRENT PREGNANCY LOSS

Inflammation, fetal infection, and previous preterm delivery are significant risk factors for preterm birth and neonatal brain injury. Rising infection with bacterial vaginosis during pregnancy is related to a risk factor for preterm delivery and low birth weight. NAC by having an anti-inflammatory outcome can affect human term and preterm labors. NAC restrains the inflammatory response with no respect whether infection is started before or after treatment initiation with the drug.

In one study, 80 women were given a folic acid supplement with NAC while another 86 women were given a supplement that solely had folic acid. All the women in the study had a history of recurrent pregnancy loss. NAC and Folic Acid compared with folic acid caused a significantly increased rate of continuation of a living pregnancy up to and beyond 20 weeks. NAC and folic acid taken together was associated with a significant increase in the take me home baby rate as compared with folic acid alone.

Source: https://www.ncbi.nlm.nih.gov/pubmed/18983759

FOLIC ACID

FOLIC ACID AND NEURAL TUBE DEFECTS

It has become a commonly known fact that the use of Folic Acid (which is part of the B vitamin group) before pregnancy prevents neural tube defects. Therefore, public health authorities all over Europe recommend an intake of 400 ug folate per day for women of reproductive age.

Despite several public health campaigns and recommendations for over two decades, the compliance to folic acid supplementation is low in many countries. Results of previous studies have shown that less than 50% of women planning a pregnancy use preconceptional folic acid supplementation.

Source: Folate-mediated one-carbon metabolism and its effect on female fertility and pregnancy viability.

Laanpere M, Altmae S, Stavreus-Evers A, Nilsson TK, Yngve A, Salumets A Nutr Rev. 2010 Feb; 68(2):99-113.

L – ARGININE

PROMOTES HEALTHY UTERINE LINING

Studies have shown that L-Arginine can help thicken the uterine lining. The thinning of the uterine lining occurs un many women and is often caused by ovulation enhancing drugs such as clomiphene citrate (commonly referred to as Clomid).

Clomid is an estrogen suppressing medication which is often prescribed by doctors to trigger ovulation. During a normal menstrual cycle, estrogen works to thicken the uterine lining to prepare for implantation of the fertilized embryo. Reproductive endocrinologists prefer the endometrial lining to be at least 8mm thick during infertility treatment. The anti-estrogenic effect of Clomid can prevent endometrium thickening in 25-30% of women.

For women with a thin uterine lining, L-arginine may help improve the thickness of the lining. Adequate thickness of the endometrium, or uterine lining, is important for supporting a pregnancy.

For women with a thin uterine lining, whether caused by estrogen suppressing drugs or not, may help with thickening of the uterine lining.

A thin lining is considered to be less than 8mm. L-arginine treatment has been shown to increase the thickness of the endometrial lining. In 6 of 9 patients with a thin lining who took L-arginine, the endometrial lining increased to greater than 8 mm.

Source: Takasaki A, Tamura H, Miwa E, et al. Endometrial growth and uterine blood flow: a pilot study for improving endometrial thickness in patients with a thin endometrium. Fertil Steril. 2010;93(6):1851-1858.

Battaglia C, Salvatori M, Maxia N, et al. Adjuvant L-arginine treatment for in-vitro fertilization in poor responder patients. Hum Reprod. 1999;14(7):1690-1697.

L ASCORBIC ACID (VITAMIN C)

Studies have shown that Vitamin C helps improve the amount and constancy of your cervical mucus.

It works by increasing the amount of water that your mucus contains. It also increases blood flow to your uterus. This makes the uterine lining hospitable for implantation and pregnancy.

Some foods high in vitamin C include oranges, strawberries, kiwi, broccoli and peppers. Try and keep your vitamin C intake to 1000 mg or lower per day. Too much vitamin C can make your cervical mucus too acidic which is very unfriendly to sperm.

Vitamin C plays a critical role in the rearranging of the cervical mucus fibers during ovulation. Without adequate Vitamin C, changes in cervical mucus around ovulation that create the sperm pathway cannot adequately occur. Vitamin C in the blood stream has also been found to penetrate cervical mucus where it can support sperm function and vaginal immunity.

ZINC GLUCONATE

Zinc is the most widely studied nutrient in terms of fertility for both men and women. It is an essential component of genetic material and a zinc deficiency can cause chromosome changes in either you or our partner, leading to reduced fertility and an increased risk of miscarriage. Zinc is necessary for your body to ‘attract and hold’ (utilise efficiently) the reproductive hormones, oestrogen and progesterone.

Source: https://www.ncbi.nlm.nih.gov/pubmed/17099205